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产品概述
| 名称 | THP-1 (人单核细胞白血病) (STR鉴定正确) |
| 别称 | THP1; THP 1; THPI; THP-1(ATCC); Tohoku Hospital Pediatrics-1 |
| 背景描述 | THP-1细胞对乳汁珠和激活的红细胞有吞噬作用，无表面和胞质免疫球蛋白。THP-1细胞可以用佛波醇、TPA诱导单核细胞分化。 |
| 种属 | 人 |
| 年龄（性别） | 男 |
| 组织来源 | 急性单核细胞白血病，单核细胞 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 单核细胞 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 白血病细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | RPMI-1640＋10% FBS＋0.05mM β-mercaptoethanol＋1% P/S |
| 推荐传代比例 | 5×10^5-1×10^6cells/mL |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~36-72 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 受体表达情况 | complement (C3), expressed;Fc, expressed |
| 抗原表达情况 | HLA A2, A9, B5, DRw1, DRw2 |
| 基因表达情况 | lysozyme, HLA A2, A9, B5, DRw1, DRw2 |
| 注意事项 | 该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 保藏机构 | ATCC; TIB-202 DSMZ; ACC-16 ECACC; 88081201 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11,13 D2S1338 17,18 D3S1358 15,17 D5S818 11,12 D7S820 10 D8S1179 10,14 D13S317 13 D16S539 11,12 D18S51 13,14 D19S433 12.2,13 D21S11 30,31.2 FGA 24,25 PentaD 10,12 PentaE 11,15 TH01 8,9.3 TPOX 8,11 vWA 16 D6S1043 14 D12S391 19 D2S441 10,11 -
STR鉴定图
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参考文献
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Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles(2022/08/23)
作者：YangLin Wu, Chenhui Zhang, Yun Teng
期刊：Military Medical Research
DOI：10.1186/s40779-022-00404-0
影响因子 ：34.9150
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HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype(2021/04/23)
作者：Yanjiao Li, Min Dong, Qing Wang
期刊：Basic Research in Cardiology
DOI：10.1007/s00395-021-00867-7
影响因子 ：12.416
引用产品：CL-0233
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Water-extracted Lonicera japonica polysaccharide attenuates allergic rhinitis by regulating NLRP3-IL-17 signaling axis(2022/09/03)
作者：Xinyu Bai, Ping Liu, Hengyan Shen
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2022.120053
影响因子 ：10.7230
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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation(2021/09/21)
作者：Tanjing Song, Qingli Zou, Yingying Yan
期刊：Cell Reports
DOI：10.1016/j.celrep.2021.109739
影响因子 ：9.995
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Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer(2021/08/30)
作者：Xiaobin Gu, Yonggang Shi, Meilian Dong
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-04087-8
影响因子 ：9.685
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The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation(2022/03/09)
作者：Yanglin Wu,Yun Teng, Chenhui Zhang
期刊：Journal Of Nanobiotechnology
DOI：10.1186/s12951-022-01320-0
影响因子 ：9.4290
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Prediction of prognosis, immunogenicity and efficacy of immunotherapy based on glutamine metabolism in lung adenocarcinoma(2022/08/11)
作者：Jichang Liu, Hongchang Shen, Wenchao Gu
期刊：Frontiers in Immunology
影响因子 ：8.7860
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MicroRNA-22 represses glioma development via activation of macrophage-mediated innate and adaptive immune responses(2022/03/12)
作者： JiajieTu, Yilong Fang, Dafei Han
期刊：Oncogene
DOI：10.1038/s41388-022-02236-7
影响因子 ：8.7560
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Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes(2022/04/04)
作者：Jiannan Zhao, Yongling Li, Jing Ma, Jingting Liu
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2022.114338
影响因子 ：7.0880
引用产品：CL-0233
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Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages(2021/04/20)
作者：Zhongwei Luo, Kun Xia, Yiwei Liu
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
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C/EBPβ is a key transcription factor of ox-LDL inducing THP-1 cells to release multiple pro-inflammatory cytokines(2021/10/04)
作者：Jun Ma, Xiangyu Yang, Xiaoping Chen
期刊：Inflammation Research
DOI：10.1007/s00011-021-01509-3
影响因子 ：6.986
引用产品：CL-0233
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Advanced glycation end products reduce macrophage‐mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation(2020/07/15)
作者：Xiaoying Xie, Chuan Yang, Chaohui Duan
期刊：European Journal Of Immunology
影响因子 ：6.688
引用产品：CL-0233
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Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head(2022/04/06)
作者：Liao Zheting, Jin Yu, Chu Yuhao
期刊：Communications Biology
DOI：10.1038/s42003-022-03271-6
影响因子 ：6.5480
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Sennoside A is a novel inhibitor targeting caspase-1(2022/09/01)
作者：Jiasi Wu, Yuejia Lan, Xiaoke Shi
期刊：Food & Function
影响因子 ：6.3170
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Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4(2022/10/20)
作者：Hongfei Liu, Jiankun Liu, Changkun Long
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：6.2080
引用产品：CL-0233
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Inhibiting vascular smooth muscle cell proliferation mediated by osteopontin via regulating gut microbial lipopolysaccharide: A novel mechanism for paeonol in atherosclerosis treatment(2022/08/11)
作者：Xiaoyan Shi, Hongfei Wu, Yarong Liu
期刊：Frontiers in Pharmacology
影响因子 ：5.9880
引用产品：CL-0233
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Ginsenoside Rg3 Alleviates ox-LDL Induced Endothelial Dysfunction and Prevents Atherosclerosis in ApoE?/? Mice by Regulating PPARγ/FAK Signaling Pathway(2020/04/22)
作者：Jianan Geng, Wenwen Fu, Xiaofeng Yu
期刊：Frontiers in Pharmacology
影响因子 ：5.9880
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ADAR1 is targeted by miR-143 to regulate IL-1β-induced endothelial activation through the NFκB pathway(2017/5/17)
作者：Yuanzhuo Chen, Hu Peng, Shuqin Zhou
期刊：International Journal Of Biochemistry & Cell Biology
DOI：10.1016/j.biocel.2017.05.021
影响因子 ：5.6520
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Neuropeptide Y regulates cholesterol uptake and efflux in macrophages and promotes foam cell formation(2022/09/29)
作者：Yu Cai, Zhengchao Wang, Lun Li
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.2950
引用产品：CL-0233
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Negative feedback loop of ERK/CREB/miR‐212‐3p inhibits HBeAg‐induced macrophage activation(2020/08/07)
作者：Wenjun Chen, Hongjun Bian, Xiaoyu Xie
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.295
引用产品：CL-0233
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miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population(2018/11/29)
作者：Suli Huang, Ziquan Lv, Ying Wen
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.295
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Calycosin represses AIM2 inflammasome-mediated inflammation and pyroptosis to attenuate monosodium urate-induced gouty arthritis through NF-κB and p62-Keap1 pathways(2022/09/07)
作者：Jing Tian, Dapeng Zhou, Liangbi Xiang
期刊：DRUG DEVELOPMENT RESEARCH
影响因子 ：5.0040
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Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms(2022/08/31)
作者：Hesuyuan Huang, Xuyang Ding, Dan Xing
期刊：MOLECULES
影响因子 ：4.9270
引用产品：CL-0233
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ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury(2022/03/10)
作者：Zhen Yu, Xiaoyu Xie, Xiaonan Su
期刊：Cellular Signalling
DOI：10.1016/j.cellsig.2022.110304
影响因子 ：4.8500
引用产品：CL-0233
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lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway(2022/10/13)
作者：Yuanxiu Gan, Jie Long, Yan Zeng
期刊：MEDIATORS OF INFLAMMATION
影响因子 ：4.5290
引用产品：CL-0233
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Chemical Syntheses and Biological Evaluation of CXCL14 and Its Site-Selectively Modified Methionine Sulfoxide-Containing Derivatives(2019/12/9)
作者：Zonghui Cai, Qijia Wei, Xiujuan Li
期刊：Journal Of Organic Chemistry
影响因子 ：4.1980
引用产品：CL-0233
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Mesenchymal stem cell exosomal tsRNA-21109 alleviate systemic lupus erythematosus by inhibiting macrophage M1 polarization(2021/08/28)
作者：Rui Dou, Xiulei Zhang, Xiangdong Xu
期刊：Molecular Immunology
DOI：10.1016/j.molimm.2021.08.015
影响因子 ：4.174
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Picroside II alleviates DSS-induced ulcerative colitis by suppressing the production of NLRP3 inflammasomes through NF-κB signaling pathway(2022/03/23)
作者：Huixiang Yao,Jun Yan,Li Yin
期刊：Immunopharmacology And Immunotoxicology
DOI：10.1080/08923973.2022.2054425
影响因子 ：3.7120
引用产品：CL-0233
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Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization(2021/11/2)
作者：Yunxiang Cao, Jian Liu, Chuanbing Huang
期刊：Journal Of Pharmacological Sciences
DOI：10.1016/j.jphs.2021.10.005
影响因子 ：3.5780
引用产品：CL-0233
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(3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages(2021/3/9)
作者：Jingwen Xu, Zhe Wang, Lianlian Sun
期刊：Toxicology In Vitro
影响因子 ：3.5000
引用产品：CL-0233
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Understanding Competitive Endogenous RNA Network Mechanism in Type 1 Diabetes Mellitus Using Computational and Bioinformatics Approaches(2021/9/8)
作者：Xuanzi Yi, Xu Cheng
期刊：Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
影响因子 ：3.2490
引用产品：CL-0233
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Regulation of Atherosclerosis by Toll-Like Receptor 4 Induced by Serum Amyloid 1: A Systematic In Vitro Study.(2022/09/15)
作者：Jinhui Chen, Gang Liu, Yan Hong
期刊：Biomed Research International
影响因子 ：3.2460
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Tumor?associated macrophage?derived exosomes promote EGFR?TKI resistance in non?small cell lung cancer by regulating the AKT, ERK1/2 and STAT3 signaling pathways(2022/08/24)
作者：Shiyang Yuan, Wenjun Chen, Jian Yange
期刊：Oncology Letters
影响因子 ：3.1110
引用产品：CL-0233
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The synergistic Reduning and cefmetazole sodium treatment of severe pneumonia is mediated by the AhR-Src-STAT3 pathway(2022/02/01)
作者：Shanjun Luo, Lianfang Gan, Shengxing Liu
期刊：Journal of Thoracic Disease
影响因子 ：3.0050
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Tyrosine kinase nonreceptor 1 (TNK1) knockdown ameliorates hemorrhage shock-induced kidney injury via inhibiting macrophage M1 polarization(2021/11/17)
作者：Miaolong Tang, Jimin Cai, Yan Wang
期刊：3 BIOTECH
DOI：10.1007/s13205-021-03042-w
影响因子 ：2.8930
引用产品：CL-0233
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Identification of Interleukin-1-Beta Inhibitors in Gouty Arthritis Using an Integrated Approach Based on Network Pharmacology, Molecular Docking, and Cell Experiments(2022/09/19)
作者：Liying Zeng, Zekun Lin, Pan Kang
期刊：Evidence-based Complementary and Alternative Medicine
影响因子 ：2.6500
引用产品：CL-0233
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Luteolin suppresses the growth of colon cancer cells by inhibiting the IL-6/STAT3 signaling pathway.(2022/08/01)
作者：Jingwen Jiang, Fengting Zhu, Hui Zhang
期刊：Journal of Gastrointestinal Oncology
影响因子 ：2.5870
引用产品：CL-0233
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MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3(2021/3/1)
作者：Xiang Wang, Jingwei Chi, Bingzi Dong
期刊：International Journal of Rheumatic Diseases
影响因子 ：2.5580
引用产品：CL-0233
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Long non-coding RNA GAS5 knockdown facilitates proliferation and impedes apoptosis by regulating miR-128-3p/FBLN2 axis in ox-LDL-induced THP-1 cells(2021/1/1)
作者：Zijian Shen, Haigang Li
期刊：Clinical Hemorheology And Microcirculation
影响因子 ：2.4110
