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产品概述
| 名称 | T-47D (人乳腺管癌细胞) (STR鉴定正确) |
| 别称 | T-47-D; T47-D; T47D:A; T47D |
| 背景描述 | T-47细胞分离自一位54岁乳房侵入性导管癌的女性患者胸水；发现分化的上皮亚株(T-47D)有细胞质连接和17-β-雌二醇及其他类固醇降血钙素的受体，T-47D细胞表达WNT7B癌基因。 |
| 种属 | 人 |
| 年龄（性别） | 女 |
| 组织来源 | 乳腺；乳房；导管；来自导管癌肋膜渗出液转移灶 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | RPMI-1640＋0.2U/ml Insulin＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~36-46 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, forms colonies in soft agar. |
| 受体表达情况 | calcitonin, expressed; androgen receptor, expressed; estrogen receptor, expressed; progesterone receptor, expressed; glucocorticoid receptor, positive, expressed; prolactin, expressed; calcitonin; androgen receptor, positive; progesterone receptor, p |
| 保藏机构 | ATCC; HTB-133 DSMZ; ACC-739 ECACC; 85102201 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,13 D2S1338 24 D3S1358 15,17 D5S818 12 D7S820 11 D8S1179 13 D13S317 12 D16S539 10 D18S51 17 D19S433 14 D21S11 28,31 FGA 23 PentaD 10,12 PentaE 7,14 TH01 6 TPOX 11 vWA 14 D6S1043 19 D12S391 19 D2S441 14 -
STR鉴定图
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参考文献
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Cadmium promotes breast cancer cell proliferation, migration and invasion by inhibiting ACSS2/ATG5-mediated autophagy(2021/01/15)
作者：Yidan Liang, Huifeng Pi, Lingzhi Liao
期刊：Environmental Pollution
DOI：10.1016/j.envpol.2021.116504
影响因子 ：9.988
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Low Dose of Paclitaxel Combined with XAV939 Attenuates Metastasis, Angiogenesis and Growth in Breast Cancer by Suppressing Wnt Signaling(2019/08/14)
作者：Dattatrya Shetti, Bao Zhang
期刊：Cells
影响因子 ：7.666
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N6-methyladenosine-mediated downregulation of miR-374c-5p promotes cadmium-induced cell proliferation and metastasis by targeting GRM3 in breast cancer cells( 2021/12/15)
作者：Yang Yue, Ping Deng, Heng Xiao
期刊： ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2021.113085
影响因子 ：7.1290
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Rapamycin antagonizes cadmium-induced breast cancer cell proliferation and metastasis through directly modulating ACSS2(2021/08/16)
作者：Yidan Liang, Lai Yi, Ping Deng
期刊：Ecotoxicology And Environmental Safety
DOI：10.1016/j.ecoenv.2021.112626
影响因子 ：7.129
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The inhibition of centromere protein K causes anticancer effects in breast carcinoma via effects on the FAK/PI3K/AKT/mTOR pathway(2022/09/09)
作者：Jiao Yu, Kai Wang, Sanhu Yang
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2022.116232
影响因子 ：4.4600
引用产品：CL-0041 CL-0114 CL-0149 CL-0228 CL-0324 CL-0525 PM150110 PM150312 PM150411
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Selinexor improves the anti-cancer effect of tucidinostat on TP53 wild-type breast cancer(2022/01/13)
作者：Yingfang Shi, Shengxi Xu, Sen Li
期刊：MOLECULAR AND CELLULAR ENDOCRINOLOGY
影响因子 ：4.3690
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Silence of α1-Antitrypsin Inhibits Migration and Proliferation of Triple Negative Breast Cancer Cells(2018/09/27)
作者：Zhijing Zhao, Junfeng Ma, Ying Mao
期刊：Medical Science Monitor
影响因子 ：3.3860
