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产品概述
| 名称 | 4T1(小鼠乳腺癌细胞) (STR鉴定正确) |
| 别称 | 4T1-A |
| 背景描述 | 4T1细胞是从410.4瘤株中未经诱变筛得的6-硫鸟嘌噙抗性细胞株。当4T1细胞注射到BALB/c小鼠中时，4T1细胞会自发产生高转移肿瘤，可转移到肺、肝、淋巴结和大脑，同时在注射部位形成始发灶，诱导转移时不需要摘除始发灶。4T1细胞在BALB/c小鼠中的生长与转移特性与人体中的乳腺癌十分相近，这种肿瘤是人Ⅵ期乳腺癌的动物模型。4T1细胞诱导的肿瘤在手术后及未手术情况下转移的动力学相近，可以用作手术后及未手术模型。4T1细胞诱导的肿瘤模型跟其他肿瘤模型相比，由于4T1细胞的抗6-硫鸟嘌噙特性，微小的转移细胞团(少到仅仅1个)也可以在许多远端器官中检测到，没必要数淋巴结或称重器官。 |
| 种属 | 小鼠 |
| 组织来源 | 乳腺组织 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | RPMI-1640＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, forms tumors and metastasizes in BALB/c mice. |
| 保藏机构 | ATCC; CRL-2539 |
STR鉴定
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STR位点信息
18-3 18,19 6-7 12 5-5 14 X-1 24,25 1-2 17 7-1 25.2 8-1 13 1-1 16 19-2 13 15-3 22.3 12-1 16,17 6-4 18 4-2 21.3 3-2 14,15 2-1 16,17 13-1 16.2 11-2 18,19 17-2 15 -
STR鉴定图
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参考文献
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作者：Jinxing Chen, Mingfu Gong, Yulong Fan
期刊：ACS Nano
影响因子 ：18.0270
引用产品：CL-0007
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9,10-Phenanthrenequinone: A Promising Kernel to Develop Multifunctional Antitumor Systems for Efficient Type I Photodynamic and Photothermal Synergistic Therapy(2021/11/30)
作者：Jingjing Guo, Jun Dai, Xiaoluo Peng
期刊：ACS Nano
影响因子 ：18.0270
引用产品：CL-0007
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A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods(2017/04/01)
作者：Qi Sun, Qing You, Xiaojuan
期刊：Biomaterials
DOI：10.1016/j.biomaterials.2017.01.021
影响因子 ：15.304
引用产品：CL-0007
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Synergistic Lysosomal Impairment and ER Stress Activation for Boosted Autophagy Dysfunction Based on Te Double-Headed Nano-Bullets(2022/05/29)
作者：Tingting Wang, Guangxu Xiao, Qianglan Lu
期刊：Small
影响因子 ：15.1530
引用产品：CL-0007
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Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies(2022/10/06)
作者：Xin Li, Sen He, Han Xiao
期刊：ENVIRONMENT INTERNATIONAL
DOI：10.1016/j.envint.2022.107568
影响因子 ：13.3520
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Image-Guided TME-Improving Nano-Platform for Ca2+ Signal Disturbance and Enhanced Tumor PDT(2021/6/24)
作者：Yuping Jiang, Wei Meng, Lijuan Wu
期刊：Advanced Healthcare Materials
影响因子 ：11.0920
引用产品：CL-0007
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Hollow Au–Cu Nanocomposite for Real-Time Tracing Photothermal/Antiangiogenic Therapy(2017/5/2)
作者：Xiaojuan Pang, Xiaoxiao Tan, Jinping Wang
期刊：Advanced Healthcare Materials
影响因子 ：11.0920
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Injectable versatile liquid-solid transformation implants alliance checkpoint blockade for magnetothermal dynamic-immunotherapy(2022/09/28)
作者：Mengna Wang, Siyu Deng, Yijia Cao
期刊：Materials Today Bio
DOI：10.1016/j.mtbio.2022.100442
影响因子 ：10.7610
引用产品：CL-0007
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Cell-penetrating corosolic acid liposome as a functional carrier for delivering chemotherapeutic drugs(2020/02/17)
作者：Xuqian Li, Andy Samuel Widjaya, Jingxuan Liu
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2020.02.013
影响因子 ：10.6330
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BSA–Bioinspired Gadolinium Hybrid-Functionalized Hollow Gold Nanoshells for NIRF/PA/CT/MR Quadmodal Diagnostic Imaging-Guided Photothermal/Photodynamic Cancer Therapy(2017/10/31)
作者：Qing You, Qi Sun, Meng Yu
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
引用产品：CL-0007
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Injectable, Biodegradable, Thermosensitive Nanoparticles-Aggregated Hydrogel with Tumor-Specific Targeting, Penetration, and Release for Efficient Postsurgical Prevention of Tumor Recurrence(2019/05/09)
作者：Huiming Liu, Xiaoguang Shi, Di Wu
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
引用产品：CL-0007
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RETURN TO ISSUEPREVRESEARCH ARTICLENEXTInjectable, Biodegradable, Thermosensitive Nanoparticles-Aggregated Hydrogel with Tumor-Specific Targeting, Penetration, and Release for Efficient Postsurgical Prevention of Tumor Recurrence(2019/05/09)
作者：Huiming Liu, Xiaoguang Shi, Di Wu, Frewein Kahsay Khshen
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.383
引用产品：CL-0007
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Self-Assembly of an Antitumor Dipeptide Induced Near-Infrared Fluorescence and Improved Stability for Theranostic Applications(2021/07/06)
作者：Weifeng Lin, Yingchun Yang, Yang Lei
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
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Persistent Luminescence Nanoplatform with Fenton-like Catalytic Activity for Tumor Multimodal Imaging and Photoenhanced Combination Therapy(2020/05/15)
作者：Shuqi Wu, Zihan Qiao, Yang Li
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
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MSOT/CT/MR imaging-guided and hypoxia-maneuvered oxygen self-supply radiotherapy based on one-pot MnO2-mSiO2@Au nanoparticles(2019/03/28)
作者：Siyu Wang, Qing You, Jinping Wang
期刊：Nanoscale
影响因子 ：8.307
引用产品：CL-0007
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A single-light triggered and dual-imaging guided multifunctional platform for combined photothermal and photodynamic therapy based on TD-controlled and ICG-loaded CuS@mSiO2(2016/12/22)
作者：Qing You, Qi Sun, Jinping Wang
期刊：Nanoscale
影响因子 ：8.307
引用产品：CL-0007
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A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots(2017/03/28)
作者：Jinping Wang, Xiaojuan Pang, Xiaoxiao Tan
期刊：Nanoscale
影响因子 ：8.307
引用产品：CL-0007
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A tungsten nitride-based degradable nanoplatform for dual-modal image-guided combinatorial chemo-photothermal therapy of tumors(2018/12/27)
作者：Cheng Zhang,Shibo Wang,Zhaoxia Chen
期刊：Nanoscale
影响因子 ：8.307
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A multimodal strategy of Fe3O4@ZIF-8/GOx@MnO2 hybrid nanozyme via TME modulation for tumor therapy(2021/09/15)
作者：Yu Zhang, Yifeng Yang, Jinsheng Shi
期刊：Nanoscale
影响因子 ：8.307
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Micelle nanovehicles for co-delivery of Lepidium meyenii Walp. (maca) polysaccharide and chloroquine to tumor-associated macrophages for synergistic cancer immunotherapy(2021/08/25)
作者：Ye Yang, Tingting Guo, Junwei Xu
期刊：International Journal Of Biological Macromolecules
DOI：10.1016/j.ijbiomac.2021.08.155
影响因子 ：8.025
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UCPs/Zn2GeO4:Mn2+/g-C3N4 heterojunction engineered injectable thermosensitive hydrogel for oxygen independent breast cancer neoadjuvant photodynamic therapy(2021/01/13)
作者：Linchao Zhang, Manli Yang, Yishun Ji
期刊：Biomaterials Science
影响因子 ：7.590
引用产品：CL-0007
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Injectable Thermosensitive Hydrogel to Enhance Photothermal Ablation and Systemic Immunotherapy of Breast Tumors(2022/08/24)
作者：Tao Qin, Ruipeng Li, Huiqin Jin
期刊：Biomaterials Science
影响因子 ：7.5900
引用产品：CL-0007
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Oxygen-rich chemotherapy via modified Abraxane to inhibit the growth and metastasis of triple-negative breast cancer(2018/11/13)
作者：Lingtong Meng, Shaoju Gan, Ya Zhou
期刊：Biomaterials Science
影响因子 ：7.590
引用产品：CL-0007
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Photosensitizer loaded PEG-MoS?–Au hybrids for CT/NIRF imaging-guided stepwise photothermal and photodynamic therapy(2017/02/24)
作者：Li Liu, Jinping Wang, Xiaoxiao Tan
期刊：Journal of materials chemistry B
影响因子 ：7.571
引用产品：CL-0007
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NIRF/PA/CT multi-modality imaging guided combined photothermal and photodynamic therapy based on tumor microenvironment-responsive nanocomposites(2018/06/18)
作者：Li Liu, Jinping Wang, Qing You
期刊：Journal of Materials chemistry. B
影响因子 ：7.571
引用产品：CL-0007
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Magnetically-targeted and near infrared fluorescence/magnetic resonance/photoacoustic imaging-guided combinational anti-tumor phototherapy based on polydopamine-capped magnetic Prussian blue nanoparticles(2018/04/06)
作者：Yidan Wang, Xiaojuan Pang, Jinping Wang
期刊：Journal of Materials Chemistry B
影响因子 ：7.571
引用产品：CL-0007
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A tailored and red-emissive type I photosensitizer to potentiate photodynamic immunotherapy(2022/08/29)
作者：Sirong Zhou, Ruipeng Li, Ying Li
期刊：Journal of Materials Chemistry B
影响因子 ：7.5710
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Synergistic Theranostics of Magnetic ResonanceImaging and Photothermal Therapy of Breast CancerBased on the Janus Nanostructures Fe3O4-Aushell-PEG(2021/09/16)
作者：Xun Kang, Tao Sun, Liang Zhang
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
引用产品：CL-0007
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Functionalized Au@Cu-Sb-S Nanoparticles for Spectral CT/Photoacoustic Imaging-Guided Synergetic Photo-Radiotherapy in Breast Cancer(2022/01/25)
作者：Honglei Hu, Shuting Zheng, Meirong Hou
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
引用产品：CL-0007
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Efficient starvation therapy with three-pathway blocking in combination with PTT/CDT for TME reversal and tumor apoptosis(2022/03/28)
作者：Mengchao Ding, Xiaoying Kong, Weiyan Chen
期刊：Journal Of Industrial And Engineering Chemistry
DOI：10.1016/j.jiec.2022.03.022
影响因子 ：6.7600
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Persistent luminescence-polypyrrole nanocomposite for dual-modal imaging and photothermal therapy of mammary cancer(2020/07/18)
作者：Shuqi Wu, Yang Li, Ruofei Zhang
期刊：Talanta
DOI：10.1016/j.talanta.2020.121435
影响因子 ：6.556
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Free paclitaxel-loaded E-selectin binding peptide modified micelle self-assembled from hyaluronic acid-paclitaxel conjugate inhibit breast cancer metastasis in a murine model(2017/05/31)
作者：Xiaofeng Han, Xuerong Dong, Jing Li
期刊：International Journal Of Pharmaceutics
DOI：10.1016/j.ijpharm.2017.05.063
影响因子 ：6.510
引用产品：CL-0007
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Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis(2022/09/09)
作者：Jia Wang, Ping Huang, Xiafang Pan
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7608
影响因子 ：6.3880
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Dendritic Cu2+-Doped Ca2SiO4 Nanosphere for Cancer Therapy via Double Ion Interference(2022/08/30)
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期刊：ACS Applied Nano Materials
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作者：Chunxi Qian, Bandar Alhamyari, Xiaofei Tang
期刊：Molecular Pharmaceutics
DOI：10.1021/acs.molpharmaceut.1c00735
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影响因子 ：4.2190
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期刊：NEW JOURNAL OF CHEMISTRY
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Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity(2018/11/18)
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期刊：Evidence-based Complementary and Alternative Medicine
影响因子 ：2.6500
引用产品：CL-0007
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期刊：Journal Of Toxicological Sciences
影响因子 ：1.7920
![C127 [C-127] (小鼠乳腺肿瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0043-1.jpg)
